From the manufacturer

Some legacy chipsets/processors from Intel prior to 8th Gen have not been updated to support memory modules featuring DDR4 16Gbit density DRAM. Check with system or motherboard manufacturer for an updated BIOS to support 16Gbit DRAM.

1. The specification of the extreme overclocking modules listed on this page may be beyond the capabilities of your AMD or Intel system hardware. Careful selection of all system components (e.g. CPU, motherboard, PSU) is required to ensure these modules will function as intended. These kits are thoroughly tested and verified in the factory to run at the listed speed for XMP Profile 1. 2. As a backup, a 2nd XMP profile at a slower clock speed is included so you can still achieve great performance if your system cannot handle the highest speed XMP profile. We cannot confirm compatibility with all systems; these modules should be installed and used at your own risk. Only select AMD and Intel based motherboards are able to achieve speeds of DDR4-4000 and above. Check motherboard Qualified Vendor Lists (QVL) to verify Renegade high speed support on the motherboard vendor website and/or Intel XMP certified list. Premium system cooling (CPU and case) are required for high-speed memory stability. On Intel platforms, X or K series processors are recommended.